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The difference is that those with RSD feel this sensitivity more frequently, more intensely, and often with less external triggering than others. Since it can be excruciating, those with RSD may also be more prone to make rash decisions in relationships to try and relieve RSD-related pain. RSD is most typically associated with ADHD, and there are some autistic folks who identify with RSD as well.

The discovery of one's neurotype typically necessitates a radical reassessment of self-expectations and accommodations. Many newly-identified autistic and ADHD individuals find themselves needing to rest differently, recognize sensory needs, implement supportive routines, and ask for appropriate help—often for the first time.